Resveratrol may be the most important supplement you can buy.  Why? Because it is by far the most powerful known activator of the "longevity" or "anti-aging" genes. What does this mean? The anti-aging genes are a group of genes which are normally not active, or "silent", meaning they are not affecting you under normal conditions. If you cut the calories you need to maintain your weight by 40% you can activate these genes, assuming we as humans respond as other mammals do.

This is very difficult for humans to do on a long term basis. Although they are called "anti-aging" genes because it is known they prolong lifespan in animal studies, they also have have hugely beneficial effects on your health. In animal models of human disease including diabetes mellitus, atherosclerosis (causing heart attack and stroke), cancer, kidney disease, Alzheimer's and Parkinson's disease, and other conditions, powerful preventive effects have been documented.  Recently, for the first time, researchers identified several chemicals which "turn on" the most important antiaging gene in animals, the Sir2, and using human cells, to turn on the corresponding gene in humans, called SIRT1.  By far the most powerful activator of these genes is Resveratrol.  Turning on the anti-aging genes is a way to good health which is only beginning to be exploited, and Resveratrol is a naturally occurring substance present in 300 plants and known to occur in high levels in certain grapes and wines. 

     It is estimated by anti-aging scientists that if a person does everything he can to promote his own good health in the form of an ideal diet, exercise, avoiding tobacco, etc., he can only increase his lifespan by about three years. This means that if you took all the other existing supplements available in the proper doses and did everything else perfectly, you can expect three more years possibly.  In contrast, animals treated by calorie restriction live 40% longer! It is clear that the relative importance of activating the anti-aging genes is far more important than other possible mechanisms to health. It is as if we have a huge repository of good health we don't know about silently residing in our genes, waiting to be activated, to go into action to prevent all the common diseases we die of. Scientists are now working to find drugs which act like Resveratrol for which accurate dosing is known.  As stated in the New York Times, Sept. 21, 2003, Dr. David Sinclair, who showed that Resveratrol increased the lifespan of yeast by 70%:

Resveratrol may be the key to tapping this potential until such time as drugs are developed which more specifically affect the genes. Resveratrol has been studied for years because it has been suspected to  improve health. Many studies in animals demonstrate the beneficial effects of Resveratrol in preventing cancer, atherosclerosis, disease of the central nervous system, etc. It is also a powerful antioxidant which contributes to its health-promoting properties. It also reduces platelet agglutination which is thought to reduce the likelihood of stroke and heart attack. It has been identified as possibly the explanation for why red wine drinkers  have a lower incidence of heart disease. These other effects may be significant, but the role Resveratrol plays in activating the anti-aging genes is likely to far outweigh these other mechanisms. 

As with most supplements, science doesn't have all the answers as to why Resveratrol works, but there seems to be no evidence that it is harmful when consumed  normally in naturally occurring forms of food or wine. The optimal dose as a supplement has not been established, but we have clues regarding its use as an activator of the anti-aging gene, SIRT1.  Two bottles of red wine  made from the types of grapes with highest concentrations of Resveratrol contain 25 mg.  A recent study in humans showed that consuming 25mg. Resveratrol produced a  peak level in the bloodstream about 1/3  the level which in cell culture is known to activate the SIRT1 gene. Resveratrol does concentrate in some organs more than others, and its effects may persist for a period of time.Therefore we feel that 25 mg-75mg perday is a safe level. Very high levels of Resveratrol (500 time greater)are toxic in cell culture . There are many plant sources of Resveratrol used to make supplements. Extracts of these plants may have levels of Resveratrol which are high.  However, most Resveratrol in these plant extracts is attached to other chemicals and is not available for use by your body. To be sure that the Resveratrol you are taking is effective and in a known dose, it must be refined to at least 98%. purity.The free, bioavailable  Resveratrol used in our capsules has been assayed independently and they are guaranteed  to contain the stated concentration. If you buy from other suppliers, you should request documentation that the level of Resveratrol is as claimed. Analysis of many supplements shows little or none of the free, bioactive ingredient in several studies. You would be wasting money if you buy such supplements.

We sell only Resveratrol because we believe it to be, based on the best science currently, by far the most important supplement a person can take.

We provide it in a quantity which we believe to be safe and which is guaranteed to be accurate.

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