About eResveratrol

DOSE OF eResveratrol™

What is the proper dose of eResveratrol™?

Red wine contains 0.5 milligram of resveratrol per 5 ounce glass. The French Paradox suggests that red wine reduces the death rate from heart disease by almost two-thirds in the French compared to Americans despite having similar cholesterol levels. Therefore, a few milligrams per day of resveratrol seems to be beneficial.

In the recent landmark study, mice fed a 60% fat, high calorie diet showed prevention of the consequences of such a diet when given 24 mg. per kg body weight, but another group of mice given 5 mg/kg body weight also showed very significant benefical effects. Dr David Sinclair, the leading researcher in resveratrol, has stated he takes 5mg per kg of body weight, which would amount to 350 mg for an average man. Dr. Johnson has taken resveratrol in a dose ranging between 200mg to 2000mg per day since Aug 2003 and has seen no ill effects and has had defnite positive effects. The 2000mg dose is comparable to the dose used in the mouse study. So far, there is no evidence of toxicity in humans despite widespread use of resveratrol supplements. Our average dietary intake of polyphenols, of which resveratrol is an example, is about 1gm per day.

At present we agree with Dr.Sinclair's opinion that 200 mg to 400 mg per day is  a safe dose to take, and higher doses may be of greater value when more testing has been done.

The decision to take this dosage is based on the appraisal of the risks and benefits. The lack of toxicity of resveratrol in many animal studies, the enormous potential benefits, and the high degree of purity of eResveratrol™ components are the basis of Dr. Johnson’s personal opinion that the 5 mg/kg dose is safe. Thus, a 70kg (154 pounds)  man would take 350 mg per day.

Another recent article in which mice were given between 200 and 400 mg/kg body weight showed a doubling of exercise endurance. This would equate to 14 to 28 grams of resveratrol for the average man, a much higher dose. When further human studies are published, such high doses may be found to be safe and of greater benefit,  but currently we do not endorse such high doses for the average individual.

 

WHAT RESVERATROL DOES:

  1. Improves neuro muscular function - coordination and balance. This means the central nervous system is functioning at a higher level and would generalize to improve mental alertness, problem solving ability (intelligence) and athletic ability.
  2. Increases muscle strength.
  3. Double exercise endurance. Muscle fibers switch to increased oxidative metabolism (fast twitch type 2 to slow twitch type 1) as seen in exercise training. In contrast, anabolic steroids increase muscle mass, but do not switch muscle fiber type.
  4. Improves insulim sensitivity. This would help prevent metabolic syndrome.
  5. Improves mitochondrial function (mitochondrial dysfunction is seen in Alzheimer's, Huntington's, cardiovascular disease, metabolic disease). Mitochondrial dysfunction causes fatty acid storage in muscle cells which is linked to insulin resistance.
  6. Decreases spontaneous locomotor activity.
  7. Reduces the size of the body fat storage mass and the size of adipocyte (fat cells).
  8. Increased lifespan of French Paradox may be due to prevention of chronic cardiovascular, neuro degenerative or metabolic disease.
  9. Deacetylates PGC-1alpha in liver and possibly in skeletal muscle. Induces mitochondrial activity, increasing oxidative type muscle fibers resistance to muscle fatigue and increases tolerance to cold. These effects cause obesity resistance and decrease insulin resistance.
  10. Prevents atherosclerosis