I have been conducting research on SIRT1 activation since May 2003. I have been taking resveratrol since August 2003 and created eResveratrol to provide a supplement of guaranteed purity to the public. In addition to selling eResveratrol, we are collecting anecdotal data from eResveratrol users (on an anonymous basis) which can be used to guide future research on resveratrol. 

Recent scientific news has documented almost miraculous benefits from resveratrol in animal studies. In fact there has never been any single drug or supplement which has even remotely shown the potential resveratrol has to prevent and treat human disease. Although resveratrol has been studied for over a decade, and shown to be an antioxidant and anti-inflammatory agent, it wasn’t until August 2003 that it was reported to prolong lifespan in yeast by up to 70%. Later, fruit flies, round worms and fish also were shown to live longer when fed resveratrol. In November 2006 a study was published showing dramatic effects in mice on a high-fat diet including prolonged lifespan. Among other benefits, the mice didn’t develop atherosclerosis despite high cholesterol levels. Most recently, mice on high doses of resveratrol were shown to have increased metabolic rate, reduced body fat, and double the exercise endurance of normal mice.

Will these effects occur in humans? The answer is yes because the same molecular pathways are present. To quote David Sinclair, the leading resveratrol researcher, "From a gene perspective, we're an upright mouse."

The life-prolonging effect of resveratrol was discovered when thousands of plant compounds were screened for their ability to activate a gene called SIRT1 which is known to be responsible for extending lifespan.  Normally, SIRT1 is active only when there is a low calorie intake, either every day or every other day. Most humans can’t restrict their calorie intake enough on a daily basis to turn on SIRT1, but most people can reduce their intake every other day. Our team has studied alternate day calorie restriction in humans and shown that this pattern of calorie intake has dramatic effects on a major disease (asthma) and drastically reduces oxidative stress, the basic cause of aging. We have created an exciting new diet which activates SIRT1 called Johnson UpDayDownDay Diet(TM) (“Dr. Johnson’s SIRT1 Lifespan Diet(TM)”) which we are writing a book about to be published in the near future. Thus, both the JUDDD diet and resveratrol activate the same genetic mechanism for optimal health and weight control.